A milestone study involving hundreds of scientists from around the world has identified 75 genomic regions associated with Alzheimer’s disease. A number of the newly discovered genetic pathways play a role in inflammation, adding weight to a growing hypothesis immune dysfunction can drive disease progression. Plus, the researchers raise the possibility of developing an Alzheimer’s genetic risk test to predict those most likely to develop the neurodegenerative condition.
Alzheimer’s disease is an incredibly complex and multifactorial condition. We know lifestyle factors play a major role in the development of the disease, however, over the last couple of decades researchers have estimated genetics influence the majority of a person’s risk. Between 60 and 80 percent of one’s Alzheimer’s risk is thought to come down to genes.